Working Upstream provides concrete evidence-based resources to inform school personnel of the challenges faced by homeless youth in schools and how to best support them. We expand current understandings of Canadian school-based experiences of homeless young people and generate concrete, evidence-informed strategies for enhancing the role of schools as sites of homelessness prevention. The Working Upstream partnership is committed to breaking down silos in order to work collaboratively towards our shared goal of creating effective school-based homelessness prevention programs that are feasible and cost-effective.